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Chapter 3. Laboratory

  • Chapter cover
  • General information on TB laboratory work
    • Communication between clinician and laboratory
    • How should specimens be collected?
  • Microscopy, culture identification, and growth-based testing
    • AFB smear
    • AFB culture
    • Culture identification
    • Growth-based DST
  • Critical concentration and minimum inhibitory concentration (MIC)
    • Critical concentrations
    • MIC-when to order and how to interpret
  • At-a Glance: Drug susceptibility testing available at 5 U.S. referral laboratories
    • Full version, Excel: Drug susceptibility testing available at 5 U.S. referral laboratories Updated: June 24, 2022. Please check often for updates
  • Molecular methods for detection of M. tuberculosis complex DNA and drug resistance mutations
    • Genes associated with drug resistance
    • Molecular tests for drug resistance
      • Probe-based tests
      • Sequence-based tests
      • Choice of molecular tests
      • Difficulties interpreting results from molecular tests
      • Molecular tests on extrapulmonary specimens
      • Molecular tests on formalin-fixed specimens
  • Therapeutic drug monitoring (TDM)
    • When to order TDM
    • Where to send a specimen for TDM
    • How to send a specimen for TDM
    • How to interpret results of TDM
  • National TB Molecular Surveillance
  • References
Product
Drug-Resistant Tuberculosis: A Survival Guide for Clinicians, 3rd edition / 2022 Updates
  • Front Matter
  • Chapter 1. Epidemiology & Background
  • Chapter 2. Diagnosis
  • Chapter 3. Laboratory
  • Chapter 4. Treatment
  • Chapter 5. Medication Fact Sheets
  • Chapter 6. Pediatrics
  • Chapter 7. Co-morbidities & Special Situations
  • Chapter 8. Monitoring & Case Management
  • Chapter 9. Adverse Reactions
  • Chapter 10. Contacts
  • Appendix 1: Expert Resources

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[virtual]
Fundamentals of Medical & Case Management of Drug-Susceptible TB
Wednesday, January 14, 2026
12:00 - 2:30 pm Pacific Time

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hand drawn tb medications in a small cup
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